The Association Between 8- OHdG Levels and Diabetic Neuropathy Patients from Sensory Functioning and Neurological Symptoms

Abstract

Objective: This clinical study aims to evaluate the risk factors association between the diabetic peripheral neuropathy (DPN) from neuropathic symptoms and nervous sensory signs in patients with DPN.

Methods: A total of 81 individuals with DPN participated in this clinical investigation. According to patients’ symptoms, the neuropathy symptom scores (NSS) and their neuropathy deficit scores (NDS) category, four symptom clusters were allocated: no symptoms, mild symptoms, moderate symptoms, and severe symptoms. The four neurological function categories were defined as no signs, mild signs, moderate signs and severe signs. We used an enzyme-linked immunosorbent assay kit to measure the levels of urine 8-hydroxy-2-deoxyguanosine (8-OHdG). All statistical tests were performed using the Statistical Package for the Social Sciences, version 25.0 (IBM-SPSS, Chicago, IL, USA).

Results: Based on the results of the   ordinary   logistic   regression, it   can   be   concluded that neuropathic sensory function deficits were not related to neuropathic symptoms in patients with DPN; age was associated with neuropathic function deficits in DPN patients; and the level of urine 8-OHdG has no correlation with neuropathic symptoms in patients with DPN.

Conclusions: In this clinical study, it can be deduced that the age was related to the neuropathic function deficits in DPN patients and the level of urinary 8-OHdG has no association with the development of neuropathic symptoms in patients with DPN.