The Role Of IL-6 In Osteoarthritis: A Comprehensive Analysis of Inflammation and Signaling Pathways

Authors

  • Chao Ge Guangxi Orthopedic Hospital, Nanning, Guangxi 530012
  • Jia Yao The second affiliate hospital of Guangxi medicine university，Nanning, Guangxi 530000
  • LiPeng Gao Guangxi Orthopedic Hospital, Nanning, Guangxi 530012
  • Yin Shen* Guangxi Orthopedic Hospital, Nanning, Guangxi 530012
  • ChaoXin Liang* Guangxi Hydroelectric Hospital,Nanning, Guangxi 530219

Keywords:

Interleukin-6, Osteoarthritis, Cytokine, Inflammation, Signal Transduction, Immunohistochemistry

Abstract

Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation, synovial inflammation, and subchondral bone changes. Interleukin-6 (IL-6) is a multifunctional cytokine that plays a significant role in immune responses, inflammation, and hematopoiesis. This review aims to provide a comprehensive overview of IL-6, it signaling pathways, and its role in OA. We will discuss the current understanding of IL-6 signaling and function, the specific signaling pathways related to IL-6 in OA, and the immunohistochemical expression of IL-6 in OA tissues. Despite extensive research, the precise mechanisms by which IL-6 contributes to OA pathogenesis remain unclear, and further investigation is necessary to elucidate its potential as a therapeutic target. This review will summarize the latest findings and highlight areas requiring further exploration to better understand the complex role of IL-6 in OA.

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Published

2025-06-30

Issue

Vol. 95 No. 3 (2025): Volume 95, Issue 3

Section

Original Articles

How to Cite

Chao Ge, Jia Yao, LiPeng Gao, Yin Shen*, and ChaoXin Liang* , trans. 2025. “The Role Of IL-6 In Osteoarthritis: A Comprehensive Analysis of Inflammation and Signaling Pathways”. Human Biology 95 (3): 1155-61. https://www.humbiol.org/Home/article/view/432.

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