MMP-13 At the Crossroads of Inflammation and Catabolism:Unraveling Signaling Cascades in Knee Osteoarthritis

Abstract

Knee osteoarthritis (KOA) is a prevalent degenerative joint disease characterized by a complex pathogenesis that involves various cytokines, inflammatory responses, and the interplay of multiple signaling pathways. Matrix metalloproteinase-13 (MMP-13) is a critical extracellular matrix-degrading enzyme that plays a significant role in the onset and progression of KOA. This review aims to provide a comprehensive analysis of the role of MMP-13 in knee osteoarthritis, investigating its relationships with cytokines, inflammatory responses, and associated signaling pathways. By elucidating these interactions, we seek to identify novel therapeutic strategies and targets for the management of KOA, thereby contributing to the understanding and treatment of this debilitating condition