Antigen Evolution from D614, to D614G, to Delta, and to Omicron Subtype Of SARS-Cov-2

Abstract

Since 2019, the antigens from Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) are keeping in evolution from initial D614, to D614G, to Delta, and to Omicron. The reasons of why the D614 subtype of SARS-CoV-2 was mutated to D614G first, to Delta second, and to Omicron third, are very importance in public health.

To determine if the “roughness” of the antigens is difference among the candidates leading to mutated to D614G, Delta, and Omicron sub-type of SARS-CoV-2. The hypothesis is that, the “roughest” antigen mutated first, the least “rough” antigen mutated last.

Seven of the peptides from SARS-CoV-2 were analyzed. The finding was that, the order for the evolution of its antigens was exactly from D614G “rough” status to Delta “precise” status, to Omicron “most precise” status.

In this paper, we would like to show the initial data how the antigens from initial D614, conducted evolution to D614G, to Delta, to Omicron of SARS-CoV-2. This finding can help the development of reagents for detecting both D614G “rough”, Delta “precise”, Omicron “most precise” antigens, or even help for the development of the vaccines against mutated SARS-CoV-2. And finally, to help the control of epidemic covid-19.

According to such order, the D614G “rough”, Delta “precise”, and Omicron “most precise” antigens of the SARS-CoV-2 can be designed in silicon, developed in laboratory, and confirmed in animals. The way should be very tough and long.